赜军医药推出手性单膦和手性双膦配体工具箱
不对称催化是合成手性化合物的最理想手段，不仅是当代有机化学学科的重点发展方向，也逐渐应用于手性药物、农药以及精细化学品的研发和工业生产中。在不对称催化反应中，手性催化剂是关键，而手性膦配体是手性金属催化剂的核心，直接影响了不对称金属催化反应的活性和选择性。赜军医药一直致力于研发原创性的特色手性膦配体，发展高效的不对称催化技术，至今已开发百余种具有原创性结构、高效的特色膦配体，服务医药、农药和精细化学品制造企业和学术机构。
最近赜军医药针对不同的不对称催化反应特点，推出两盒手性膦配体工具箱：手性单膦配体工具箱和手性双膦配体工具箱。手性单膦配体工具箱收集了赜军最具代表性、不同结构特征的18个P-手性单膦配体（另赠两个消旋单膦配体），可用于各类不对称偶联及其他不对称催化反应的研究和优化中；手性双膦配体工具箱收集了20个特色的手性双膦配体，可用于各类高效的不对称氢化及其他不对称催化反应的研究和优化。赜军还能为客户提供个性化的配体结构研发和规模化配体制备服务。
Zejun Monophosphorus Ligand Kit
Zejun monophosphorus ligand kit is a collection of eighteen representative P-chiral monophosphorus ligands developed in Professor WenjunTang's group (http://wenjuntang.sioc.ac.cn) that are being applied to various metal-catalyzed asymmetric transformations, including asymmetric Suzuki-Miyaura cross-coupling, asymmetric dearomative cyclization, asymmetric α-arylation, asymmetric C-H functionalization, asymmetric Heck reaction, asymmetric hydroboration, and et al. The ligand kit can serve for user’s purpose to optimize reaction conditions as well as explore new asymmetric transformations. For comprehensive reviews of P-chiral phosphorus ligands, please refer to: Acc. Chem. Res. 2019, 52, 1101; Aldrichimica Acta 2020, 53, 27; The Strem Chemiker. 2019, XXXI, 1). (Two racemic ligands, BI-DIME and AntPhos, are included as gifts for users.)
Zejun Bisphosphorus Ligand Kit
Zejun bisphosphorus ligand kit is a collection of twenty representative P-chiral bisphosphorus ligands developed in Professor Wenjun Tang’s group (http://wenjuntang.sioc.ac.cn) that are being applied to asymmetric hydrogenation as well as various other asymmetric transformations. The ligand kit can serve for user’s purpose to achieve high enantioselectivities and TONs in asymmetric hydrogenation as well as to explore new asymmetric reactions. For comprehensive reviews of P-chiral phosphorus ligands, please refer to: Acc. Chem. Res. 2019, 52, 1101; Aldrichimica Acta 2020, 53, 27; The Strem Chemiker. 2019, XXXI, 1).
赜军医药致力研发和提供全球领先的绿色催化技术包括特色手性膦配体、手性双胺和聚合型膦配体，特色手性药物砌块和原料药，服务国内外医药、农药和精细化学品制造企业和学术机构。公司秉承“化学创造未来”的企业理念，聚焦高效、经济、节能和环保的催化合成技术研发，发展顶尖的交叉偶联、不对称氢化和不对称转移氢化等催化技术，提供原创性的原料药或手性砌块合成工艺，努力为推动药物绿色制造做出积极贡献。
